S100A8/A9 levels are generally low or not detectable in squamous carcinoma cells, whereas in inflammatory or hyperproliferative oral lesions and HNSCC tissues, S100A8/A9 complex is markedly down-regulated at both mRNA and protein levels compared to normal mucosa [31], [32]. This evidence concerns the gene IGKV1D-22 and head and neck squamous cell carcinoma.