Therefore, we have designed the present study to; i) find male infertility risk associated with c.203G>A, c.1298A>C, and c.1793G>A polymorphisms in the MTHFR gene, ii) undertake meta-analysis on c.1298A>C to have a pooled estimate regarding its impact on infertility risk, and iii) correlate biochemical levels of homocysteine and folic acid with infertility. Here, MTHFR is linked to male infertility.