IFNL3 and chronic hepatitis C virus infection: Recently, several independent genome-wide association studies have shown that genetic polymorphisms at or near the interleukin 28B gene (IL28B; also known as interferon [IFN]-λ-3), including rs12979860, rs12980275, and rs8099917, are associated with higher rates of sustained virologic response (SVR) in patients with chronic hepatitis C (CHC) treated with peginterferon (PEG-IFN) alpha and ribavirin [1]–[4].