As reported previously, Akt inhibitor perifosine have shown better antiproliferative effects in Relapsed/Refractory Waldenstrom’s Macroglobulinemia [47] and Jeong et al also reported that Akt inhibitor and mTORC1 inhibitor synergistically increased cell death in NSCLC cells [48]. The gene discussed is AKT1; the disease is Waldenstrom macroglobulinemia.