Our data showed that mTORC2-associated Akt ser473-FOXO1 signaling pathway was highly activated in EGFR TKI-resistant NSCLC cells in the basal state and in vitro mTORC1 and mTORC2 kinase activities verified these results.(Fig. 1 and 2). Here, FOXO1 is linked to non-small cell lung carcinoma.