Taken together, our results showed that although both EGFR TKI-sensitive and -resistant NSCLC cells had higher mTORC1 and mTORC2 expression in the basal state, EGFR TKI-resistant cells had higher mTORC2 kinase activity, whereas EGFR TKI-sensitive cells had higher mTORC1 kinase activity. Here, EGFR is linked to non-small cell lung carcinoma.