The upregulation of c-Myc transcripts and protein by the C-terminally deleted form of Runx1 is important in the context of Runx1 mutations and translocations that remove the C-terminus and are associated with cancerous transformation; full-length Runx transcription factors may serve as tumor suppressors that tune down the expression of oncogenic c-Myc. Here, RUNX1 is linked to neoplasm.