TLR4 and heart failure: As shown in Figure 2, at day 1 after ICV injection of TLR4-SiRNA, the expression and activity of brain TLR4 were significantly lower in MI-induced heart failure treated with TLR4-SiRNA than in that treated with hGAPDH-SiRNA, and partially silencing brain TLR4 was continued for around 4 days.