Maximum rate of rise of LV pressure (LV dP/dtmax, parameter of LV systolic function) was significant higher, and highest rate of decline in LV pressure (LV -dP/dtmax, parameter of LV relaxation and ventricular filling) was significantly lower in MI-induced heart failure treated with TLR4-SiRNA than in that treated with hGAPDH-SiRNA for 2 weeks. This evidence concerns the gene TLR4 and heart failure.