Compared with controls, haplotype C-A-A in RAGE gene was overrepresented in patients (Study power: 99.5%), and was associated with a 2.1-fold increased risk of lung cancer (95% CI: 1.52–2.91) before adjustment and a 2.15-fold increased risk after adjustment (95% CI: 1.55–2.97). This evidence concerns the gene AGER and lung carcinoma.