Although none of the SNPs exceeded the significance level after correcting for multiple comparisons, at a reduced threshold of 0.001, rs1884361 (NRG3) was associated with ESCC risk, and rs9387033 (FYN), rs9788973 (MAP2K4), rs7187863 (PLCG2), and rs7720677 (PRLR) were associated with GC risk. The gene discussed is NRG3; the disease is esophageal squamous cell carcinoma.