Activation of INFS by transfection of nuclear FGFR1 was shown to induce an exit from the cell cycle, morphological differentiation and the expression of neuron-specific proteins in PC12 cells (present study), human brain- [1] or umbilical cord blood-derived Neural Progenitor Cells [23], mESC [24], neoplastic medulloblastoma and neuroblastoma cells [1], [23], [29]. The gene discussed is FGFR1; the disease is neuroblastoma.