In support of a role for TNFR2 in promoting T cell death, Kim et al. found that memory CD8 T cells lacking TNFR2 underwent greater expansion than WT TCR transgenic T cells and offered superior tumor control, attributed to resistance of the TNFR2-/- CD8 T cells to activation induced cell death [44]. The gene discussed is CD8A; the disease is neoplasm.