While association between MCP-1 and liver damage has been implied due to the findings that specific non-malignant cells are major source of MCP-1, such as the hepatic stellate cells that are known to be involved in the development of fibrosis and cirrhosis [40], [41], such MCP-1 expression occurs during more profound acute liver injury [42], [43]. This evidence concerns the gene CCL2 and fibrosis.