A second paper by Wang et al. studied the effect of glycan removal on sensitivity to various neutralizing mAbs and found that several mutation of PNGS in V4/V5 and C2/C3/C4 regions of gp120 from a Chinese BC strain alter neutralization sensitivity of these mAbs to a variable extent, but consistently reduced sensitivity to the glycan specific PG16 [22]. This evidence concerns the gene ITIH4 and breast cancer.