majorana possess an anti-invasive and anti-metastatic effects against the highly proliferative and highly invasive human MDA-MB-231 breast cancer cell line by modulating the activity and/or the expression of proteins regulating the process of cellular migration, adhesion invasion and angiogenesis such as E-cadherin, ICAM-1, MMP-2, MMP-9, uPAR and VEGF at least partly through inhibition of the NFκB and NO signaling pathways. This evidence concerns the gene ICAM1 and breast cancer.