In fact, studies showed that inactivation of NFκB in MDA-MB-231 breast cancer cells inhibit the expression of many downstream target genes involved in tumor metastasis such as MMP-2 [53], MMP-9 [16,60,61], VEGF [61], ICAM-1 [16] and uPAR [16]. The gene discussed is MMP2; the disease is breast carcinoma.