These data taken together suggest that 1) the normalization of lymphatic transport in anti-VEGF-A treated animals likely reflects alterations in tumor vascular physiology: reduced vascular leak resulted in less interstitial fluid to transport; and 2) VEGF-C and NRP2 regulate lymph transport in distal tumor-associated lymphatic vessels through different mechanism than VEGF-A. This evidence concerns the gene NRP2 and neoplasm.