The notion of tumor to lymphatic signaling in metastatic disease is also supported by clinical findings that in metastatic breast, prostate, colon and head and neck squamous cell carcinoma, expression of the pro-lymphangiogenic growth factors VEGF-C or -D in tumor and associated stromal cells correlates with increased incident of metastatic disease [11], [19]. Here, VEGFC is linked to metastatic neoplasm.