VEGFC and neoplasm: Although lymphatic pulsatile frequency was increased in control IgG treated C6 tail xenograft tumor-bearing animals compared to naïve animals, valve density or morphology was not altered compared to naïve animals, nor altered with anti-NRP2B, anti-VEGF-C or anti-VEGF-A treatment, suggesting that valve density does not account for the modulation in lymph movement.