KCNE1 and atrial fibrillation: But for Caucasian population, the increased risk of AF was observed in heterozygote comparison and dominant model, but not in homozygous comparison and recessive model (Table 2) Analyses by source of control showed that there was significant association between the rs1805127 polymorphism of KCNE1 and increased risk of AF both in HB and PB studies (Table 2).