A recent study showed knockdown of RPL37 in mouse embryonic stem cells or induced pluripotent stem cells led to the upregulation of multiple p53 targets including p21, Mdm2, Pidd, Puma, Noxa, and Bax [40], while we found the ectopic expression of RPL37 in human osteosarcoma cells led to the selective upregulation of p21 and Puma but not Mdm2, Noxa or Bax. The gene discussed is PIDD1; the disease is osteosarcoma.