Likewise, C57BL/6 Rag2-deficient mice (that entirely lack functional lymphocytes) eating Westernized diets were unprotected from obesity after eating L. reuteri (N = 7 mice/group; body weight of mice eating Western diet = 42.94±1.19 g versus Western diet+L reuteri = 41.78±1.45, p = 0.1 not significant). The gene discussed is RAG2; the disease is obesity due to melanocortin 4 receptor deficiency.