Increased density of the HNF4A band relative to beta actin was found in homogenates from hypercholesterolemia plus sham- and hypertension plus hypercholesterolemia group compared to controls, indicating up-regulation of HNF4A protein expression after exposure to hypertension and/or hypercholesterolemia (Figure 22C). The gene discussed is ACTB; the disease is Hypercholesterolemia.