GK and diabetes mellitus: GK is a potential target for pharmacological treatment of DM, as evidenced by the fact that GK-knock out mice exhibited mild hyperglycemia, while the over expression of GK lead to a relative lower blood glucose concentration in the diabetic models [41].The antihyperglycemic action of FYGL was also probably associated with the GK activity as we observed that the hepatic GK activity of diabetic mice was significantly lower than that of the normal mice, whereas supplement of FYGL increased the GK activity in a dose-dependent manner.