This observation implies that foxp3+ Tregs may rely on direct interaction with CD8a+ T cells to exert its suppressive effect on CD8+ T cell anti-tumor function in the non-immunized mouse group, whereas, VLP immunization reduces the foxp3+ Treg population and thus the suppression exerted by foxp3+ Tregs in the tumor tissue may be alleviated. This evidence concerns the gene FOXP3 and neoplasm.