Moreover the atrophy and MTr decrease in prefrontal and temporal cortex along with other neuroimaging [18], [19], [21], [22], [52], [53], [54], [55], functional [56], [57] and pathological data [26], [27], [28], [58], [59] support the clinical [60], [61] and immuno-histochemical [62] overlap between ALS and FTD which can be considered a clinico-pathological spectrum described with the label of TDP-43 proteinopathies [63]. This evidence concerns the gene TARDBP and proteostasis deficiencies.