The FISH technique is actually standardized at prognostic and predictive level in the evaluation of the Her-2/gene in breast [10] and gastric cancer [11], ALK gene in lung adenocarcinoma [12,13], 1p/19q in oligodendroglioma [13] and in several gene rearrangements in lymphoma [44]. The gene discussed is ERBB2; the disease is gastric cancer.