Fluorescence in situ hybridization (FISH) technical analysis offers one of the most sensitive, specific, and reliable strategies (i.e the Her-2 status in breast [10] and gastric carcinoma [11], ALK gene in lung carcinoma [12], 1p and 19q chromosomal status in oligodendroglioma [13], for identifying acquired chromosomal changes on routinely available formalin-fixed and paraffin embedded tissue sections. Here, ALK is linked to oligodendroglioma.