CCNE1 and lymphoma: Our results showed that overexpression of Ik11 enhances cell proliferation of both myeloid and lymphoid cell lines by modulating the protein levels of three of the major actors involved in the G1 checkpoint and G1-S transition, such as p21 and p27 cyclin-dependent kinase inhibitors and cyclin E. Interestingly, p27 and cyclin E deregulation has been already found in lymphomas [48].