In addition, constitutively active STAT3 was targeted in HPV16 positive cervical cancer cell lines in vitro by different STAT3-specific siRNA that knock down STAT3 expression or treatment with STAT3 inhibitors like AG490 and curcumin that block STAT3 phosphorylation to determine the role of active STAT3 in HPV16-mediated cervical carcinogenesis. Here, STAT3 is linked to cervical carcinoma.