NPHS2 and HIV-associated nephropathy: Furthermore, in a comprehensive analysis of the differential sensitivity to HIV nephropathy among mouse strains, a phylogenetic tree of laboratory mouse strain correlated closely with the susceptibility of strains to HIV nephropathy; strains related to C57BL/6 were resistant to HIV nephropathy and shared a gene regulatory network that included increased expression of Nphs2 (Podocin), while strains genetically related to BALB/c and FVB showed a distinct gene regulatory network and were sensitive to experimental HIV nephropathy [21].