MYH9 and kidney disorder: In turn, this might provide key insight into the mechanisms of Myh9-related disease in humans, as analysis of clinical data from affected families with autosomal dominant Myh9 disease reveals that adults have an all-or-nothing phenotype of kidney disease, either proteinuria with end stage kidney disease as young adults, or no proteinuria with normal renal function, all members of the family having similarly severe platelet defects and the identical autosomal dominant mutation.