Furthermore, the impairment of β-cell growth and overt glucose intolerance shownin a β-cell-specific IR knockout (βIRKO) mouse [28] or an IRS-2 null mouse [29] are relevant to AKT-mediated anti-apoptotic and proliferative mechanisms [30], [31] regardless the involvement of Wnt signaling. Here, AKT1 is linked to Glucose intolerance.