IFNA1 and Cirrhosis: While HCV genotype 1 infected non-responder patients with cirrhosis showed increased LPS receptor (sCD14) levels, HIV/HCV co-infected patients sCD14 (LPS receptor) levels correlated also with the severity of liver disease and predicted unfavorable response to P/R which suggests that in non-responders an overall higher innate immune activation with higher endogenous IFN production might be present, which might render the immune cells less sensitive to exogenous IFN [38].