In conjunction with evidence that multiple members of the cysteine-methionine metabolic pathway are present on hepatic CLD, the ability of diet to influence CLD-BHMT interactions raises the possibility that CLD may contribute to hepatic metabolic functions by providing a platform for coordinating enzymatic reactions associated with cysteine-methionine metabolism. Here, SLC26A3 is linked to congenital secretory chloride diarrhea 1.