Indeed several reports suggest that Stx1 and especially Stx2 may interact with LPS, thus dramatically increasing LPS toxicity to the cells; injection of mice with the combination of Stx2 and LPS resulted in a severe hemolytic-uremic syndrome (HUS) as compared to a milder effect caused by Stx2 only [43]. This evidence concerns the gene STX1A and hemolytic-uremic syndrome.