In addition, the reintroduction of the wild type (WT) FLCN protein into the FLCN-deficient human renal cell carcinoma cell line UOK257 suppresses their growth as colonies in soft agar and restricts their growth as tumors when xenografted in SCID mice [14], [15]. The gene discussed is FLCN; the disease is hereditary clear cell renal cell carcinoma.