FLCN K508R is expressed at levels comparable to the exogenously expressed WT FLCN, while the truncating mutants FLCN 1–469 and FLCN ΔF157 display decreased stability (Figure 3A), which is in agreement with previously reported data demonstrating reduced protein stability for tumor-associated FLCN truncating mutants [29]. Here, FLCN is linked to neoplasm.