IFNA1 and systemic lupus erythematosus: For example, EBV is stronglyassociated with lupus and viral load is increased with the disease flares [54,55].As IFNs are a key pathogenic factor for lupus pathogenesis, this research mayprovide possible mechanism for the failure of Rituximab in the treatment of lupus:the potentiation for IFN production as well as the low level induction of IFNs byCD20-Ab alone (Figures 1 and4B).