As TLR pathways are critical for lupus pathogenesis, we had tested if TLR3, TLR7, orTLR9 agonists (dsRNA, imiquimod, and ODN2395 respectively) and CD20 antibody for IFNinduction, the enhancement by CD20-Ab was not observed (data not shown). The gene discussed is TLR3; the disease is systemic lupus erythematosus.