In this light, DC genetically engineered to secrete a VEGF/vascular permeability factor decoy receptor that neutralizes soluble VEGF and precludes signaling in DC resulted in increased expression of costimulatory molecules and proinflammatory cytokines/chemokines by DC and improved CTL activity and anti-tumor immune control in a murine colon cancer model (157). This evidence concerns the gene VEGFA and colonic neoplasm.