TGFB1 and neoplasm: Similarly, in a murine myeloma model, tumor-derived IL-6, IL-10, and TGFβ were all shown to contribute to p38 MAPK signaling-mediated effects on BMDC maturation that led to decreased production of IL-12 and increased production of IL-10 by DC, and these cells elicited poor tumor-specific TH1, CTL, and antibody responses (125).