FOXP3 and cancer: Importantly, the ratio of the Foxp3+ nTregs versus IL-10+ Tr1 cells was touted to be key to better outcome as the one patient that remained cancer-free showed a dwindling pattern in the frequency of CD4+Foxp3+ cells while the Tr1 cell numbers steadily increased with each cycle of T-cell infusion and ex vivo PBMC stimulation.