CD4 and ovarian cancer: In support of this idea, ex vivo stimulated PBMCs of ovarian cancer patients who had better survival outcomes upon previous infusion with Th1-like CD4+ cells, contained higher fractions of both CD4+CD25+CD45RO+FoxP3+ and CD4+CD25−FoxP3−IL-10-producing cells compared to cells derived from short-term survivors (30).