FOXN1 and Immunodeficiency: The expression of Forkhead-box transcription factor n1 (Foxn1) approximately at E11.5 is crucial for the subsequent epithelial differentiation, since in its absence, the colonization of the anlage by T cell progenitors from the bone marrow fails (62) and the subsequent T cell development and TECs formation is aborted, resulting in a severe immunodeficiency (63, 64, 154, 66).