In humans many autoinflammatory disorders are treated blocking IL-1β [i.e., Familial Mediterranean fever (FMF), Pyogenic arthritis, pyoderma gangrenosum, acne (PAPA), CAPS, Hyper IgD syndrome (HIDS), Adult and juvenile Still disease Schnitzler syndrome, TNF receptor-associated periodic syndrome (TRAPS), Blau syndrome; Sweet syndrome, Deficiency in IL-1 receptor antagonist (DIRA)]. The gene discussed is IL1B; the disease is hyperimmunoglobulinemia D with periodic fever.