VEGFA and neoplasm: This is a multifunctional protein that is expressed on the surface of both tumor and stroma cells, including macrophages (Yan et al., 2005; Nabeshima et al., 2006), and through homophilic EMMPRIN:EMMPRIN interactions between these two cell types may induce the expression of both MMPs and VEGF and increase angiogenesis (Tang et al., 2004, 2005; Yurchenko et al., 2010).