Likewise, expression of membranal EMMPRIN on the tumor cells that was 2–3-fold higher in the single cultures than in the U937 cells, was increased during co-culture (by 4-folds and 3-folds in the A498 and MCF-7 cells, respectively, p < 0.05 and p < 0.001 relative to the singe cultures). Here, BSG is linked to neoplasm.