There are over 40 human BTB-ZF family members, many of which are implicated in both haematopoietic and epithelial cancers, where they act as oncogenes (e.g. BCL6, ZBTB7) or tumour suppressors (e.g. PLZF, HIC1) [reviewed in 38]. The gene discussed is ZBTB7A; the disease is neoplasm.