Abrupt thus joins a growing list of BTB-ZF proteins with potent oncogenic potential, including another Drosophila member of the family, Lola, which cooperates with the ectopic expression of the Notch ligand, Delta, to form metastatic tumours in Drosophila[37], as well as numerous mammalian BTB-ZF proteins that are also implicated as human oncogenes [reviewed in 38]. The gene discussed is CREBZF; the disease is neoplasm.