We next assessed the signaling pathways that are affected by NTRK3, which have been shown to include the MAPK/Erk, NF-κB and PI3K/Akt pathways, to determine if they may be mediating NTRK3 induced apoptosis in the colon cancer cell lines [18]. The gene discussed is NFKB1; the disease is malignant colon neoplasm.