Interestingly, we found a direct correlation between NT-3 expression and NTRK3 expression in the normal colon and in the CRC's (r2 = 0.81, Pearson's correlation P<0.0001), suggesting that the presence of NT-3 relieved the selective pressure to silence NTRK3 (Figure 3B). Here, NTRK3 is linked to colorectal carcinoma.