Nevertheless, the observed significant reduction in p-FAK, p-Src, p-PI3-K, p-c-Cbl, p-myosin IIA and p-clathrin due to EphA2 knockdown suggested that EphA2 must be acting as the master coordinator to amplify these signals to regulate virus entry, and reduced levels of these signals could be the potential reason for the dramatic reduction in KSHV entry and infection. The gene discussed is CBL; the disease is infection.