However, we still observed significant colocalization between EphA2 with KSHV (Figure 11B1) even in c-Cbl knockdown HFF cells, similar to control siRNA treatment or virus only infection in the absence of any si-RNA as validated from synchronous green (EphA2) and red (KSHV) signal (Figure 11B1, second, third and fourth panel) (∼80% colocalization frequency, Figure 11B2). This evidence concerns the gene CBL and infection.