Recently, we showed that 2′–5′ oligoadenylate synthetase (OAS)-like 1 (OASL1), an IFN-stimulated gene (ISG), is a novel translation inhibitor of IRF7, the IFN-inducible IFN-I master TF, and negatively regulates robust IFN-I production during acute viral infections [32]. The gene discussed is OASL; the disease is viral infectious disease.