IRF3 and infection: Consistent with this expectation, Oasl1 KO mice turned out to be more resistant to chronic LCMV CL-13 infection as well as acute LCMV Arm infection (Figs. 1F and S3), although LCMV is equipped with nucleoprotein (NP), a virus-derived IFN-I negative regulator that interferes with activation of IRF3 [42]–[44].