SPDEF and lymphoma: Other proteins, such as Androgen Receptor, SPDEF (SAM pointed domain-containing Ets transcription factor), ERG (Ets-Related Gene), FL1 (Follicular lymphoma, susceptibility to, 1), display typical site-specific DNA-binding profiles of transcription factors in which a strong signal occurs at the binding site, accompanied by disorganized surrounding patterns indicative of active, fluidic chromatin (Figure 2).