Moreover, mice deficient of or with modified versions of TLR2, TIRAP, MyD88 and/or IRAK4 were more susceptible to infection with Staph. aureus, En. faecium and/or Strep. pneumoniae infection (Takeuchi et al., 2000; Hoebe et al., 2005; Deshmukh et al., 2009; Leendertse et al., 2008; Pennini et al., 2013; Albiger et al., 2005). The gene discussed is IRAK4; the disease is infection.