HHcy has also been shown to aggravate Angiotensin-II mediated inflammatory effects such as inflammatory cell infiltration into tunica adventitia of arteries, and elevation of interlukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) levels in the plasma of mice bearing homozygous apolipoprotein E (ApoE) deletions in a model of Abdominal aortic aneurysm (AAA). The gene discussed is APOE; the disease is abdominal aortic aneurysm.