Subsequent analyses, however, showed that the strongest associations with AMD across the CFH-CFHR3-CFHR1 region were independent of the CNP147 deletion (23,24) and resulted from non-coding or synonymous variants lying within a small 32 kb region in the CFH gene between rs203687 in intron 9 and rs1329427 in intron 15 (25). This evidence concerns the gene CFHR3 and age-related macular degeneration.