CFH and age-related macular degeneration: The direct effects of the two non-synonymous CFH SNPs on AMD risk were either protective (rs800292 minor allele) [(odds ratio for one extra copy of the minor allele was 0.47 (95% CI 0.36–0.62)] or increased risk [odds ratio for one extra copy of the minor allele was 1.69 (95% CI 1.33–2.13)].