For the analysis of genetic effects on AMD risk, two case–control series were combined: the SAMD case–control series (31), which included a subset of 242 advanced AMD cases (atrophic or neovascular type) and 201 controls in whom both plasma CFH and CFHR1 had been measured, and an English AMD (EAMD) case–control series with 874 advanced AMD cases and 418 controls (31) (Supplementary Material, Table S1 and Fig. S1). Here, CFHR1 is linked to age-related macular degeneration.