This pathway is strongly implicated in AMD risk (9), since several components are either present in diseased tissues, such as the characteristic extracellular drusen deposits (CFH, C3b/iC3b, BF, C5b-9), or they are genetically associated with disease risk (C3, C2/BF, CFH, CFHR1, CFHR3, CFI) (10,11). Here, CFHR1 is linked to age-related macular degeneration.