These Mcl1LJAM -specific changes in the steady state expression of Noxa and Bim are also observed, when Mcl1L or Mcl1LJAM are expressed in leukaemia cell lines (Supplemental figure S2), suggesting that the specific accumulation of Noxa or Bim depends on structural characteristics of Mcl1L and Mcl1LJAM, respectively. This evidence concerns the gene PMAIP1 and leukemia.