BRD4 remains bound to transcriptional start sites of genes expressed during mitosis and affects the transcription of growth- and survival-promoting genes.15 Interestingly, a recent screen of an short hairpin RNA library targeting known epigenetic modifiers has identified BRD4 as the main factor that supports the maintenance of acute myeloid leukaemia (AML) stem cells.16 This evidence concerns the gene BRD4 and acute myeloid leukemia.