For example, it has been previously observed that ectopic MYC expression was unable to prevent JQ1-induced cell death16 and that resistance to JQ1 can occur despite c-Myc downregulation.19 Our results support the notion that BET inhibition exerts an anti-tumour effect by a variety of mechanisms and that the cytotoxic effect of BET inhibition expands beyond c-Myc downregulation. This evidence concerns the gene DNER and neoplasm.