It has been reported that inhibition of the c-Myc-induced transcriptional program represents one of the principal mechanisms of cellular killing caused by BET inhibition.17, 18, 19, 20 Consequently, the BET inhibitor JQ1 suppresses c-Myc-driven malignancies, such as nuclear protein in testis-midline carcinoma, AML and multiple myeloma, by displacement of BRD4 from the MYC promoter/enhancer.17, 18 In this study, we have shown that BET inhibition downregulates not only MYC transcription but also reduces stability of c-Myc protein. This evidence concerns the gene DNER and plasma cell myeloma.