The finding that the stress-responsive SUMO-2 is likely most relevant to HD pathogenesis over basal SUMO-1 modification by regulating the accumulation of HMW and likely poly-SUMOylated protein is consistent with the prevailing literature that chronic expression of mutant HTT causes cellular stress, including oxidative stress (Turner and Schapira, 2010). The gene discussed is SUMO1; the disease is Huntington disease.