SUMO2 and Huntington disease: Although we cannot conclude from these data that the increased SUMO-2 reactivity represents an increase in mutant HTT SUMO-2 modification per se, a HTT antibody raised against aa 115–129 shows a similar pattern of increased HMW HTT species in HD samples compared to controls (Figure 7D), suggesting that HTT is included in the proteins that accumulate in HD striata.