In the present study, apart from hyperglycemia and blood lipid disorder (more details were referred to in our recent report [18]), we provided evidence of swollen ER and induction of GRP78, CHOP, JNK and Caspase-12 in diabetic beta cells, which are predominately regulated under conditions of severe and prolonged ER stress. This evidence concerns the gene HSPA5 and Hyperglycemia.