Proteomic analysis has identified a group of proteins expressed at low levels in CML-CP but at high levels in CML-BC: HSP90, RB, AIF, PP2A, BCL2, XIAP, SMAD1, SSBP2α, PARP, GAB2, and TRIM24. Here, RB1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.