Ruiz-Torres et al. [19] studied thrombotic microangiopathy patients with congenital ADAMTS13 deficiency and patients with ADAMTS 13 inhibitors, and they reported that four of out of six patients (66%) showed a moderate decrease of C3 in the acute phase, which was indicative of complement activation and consumption. The gene discussed is ADAMTS13; the disease is hyperinsulinemic hypoglycemia, familial, 4.